Effects of intravenous cocaine are partially attenuated by haloperidol.

  title={Effects of intravenous cocaine are partially attenuated by haloperidol.},
  author={Michael Sherer and Karen M. Kumor and Jerome H. Jaffe},
  journal={Psychiatry research},
  volume={27 2},
We examined the effect of the dopaminergic blocking agent, haloperidol, on the subjective and physiologic response to cocaine in cocaine-using volunteers. Five subjects received cocaine (40 mg) or placebo administered intravenously 20 min following pretreatment with haloperidol (8 mg) or placebo intramuscularly in a randomized double-blind study design. Haloperidol pretreatment attenuated cocaine-induced increases in systolic and diastolic blood pressure but not heart rate. Pretreatment with… CONTINUE READING

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