Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition.

@article{Buggy2000EffectsOI,
  title={Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition.},
  author={Donal J. Buggy and Beverley Nicol and David J. Rowbotham and D G Lambert},
  journal={Anesthesiology},
  year={2000},
  volume={92 4},
  pages={1067-73}
}
BACKGROUND Many anesthetic agents are known to enhance the alpha1beta2gamma2S gamma-aminobutyric acid type A (GABAA) chloride current; however, they also depress excitatory neurotransmission. The authors evaluated two hypotheses: intravenous anesthetic agents inhibit glutamate release and any observed inhibition may be secondary to GABAA receptor activation. METHODS Cerebrocortical slices were prepared from Wistar rats. After perfusion in oxygenated Krebs buffer for 60 min at 37 degrees C… CONTINUE READING

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