Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise.

@article{Medved2004EffectsOI,
  title={Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise.},
  author={Ivan Medved and Malcolm J. Brown and Andrew R. Bjorksten and Michael J. McKenna},
  journal={Journal of applied physiology},
  year={2004},
  volume={96 1},
  pages={
          211-7
        }
}
The production of reactive oxygen species in skeletal muscle is linked with muscle fatigue. This study investigated whether the antioxidant compound N-acetylcysteine (NAC) augments time to fatigue during prolonged, submaximal cycling exercise. Seven men completed a double-blind, crossover study, receiving NAC or placebo before and during cycling exercise, comprising 45 min at 70% of peak oxygen consumption (Vo2 peak) and then to fatigue at 90% Vo2 peak. NAC was intravenously infused at 125 mg… Expand
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N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals.
TLDR
NAC improved performance in well-trained individuals, with enhanced muscle cysteine and GSH availability a likely mechanism. Expand
Influence of N-acetylcysteine administration on pulmonary O2 uptake kinetics and exercise tolerance in humans
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The results suggest that exercise-induced redox perturbations may contribute to fatigue development in recreationally-active adults. Expand
Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise
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It is suggested that an acute dose of NAC reduces RMF during heavy exercise, suggesting that oxidative stress is a contributing factor. Expand
Effects of oral N-acetylcysteine on fatigue, critical power, and W′ in exercising humans
TLDR
It is demonstrated that oral NAC was successful in extending time to fatigue at 80% Pmax but not at higher work rates, and there were no significant differences in V(O2) kinetics. Expand
N-acetylcysteine alters substrate metabolism during high-intensity cycle exercise in well-trained humans.
TLDR
It is suggested that NAC alters substrate metabolism and muscle fibre type recruitment during HIIE, which is detrimental to time-trial performance. Expand
ffects of oral N-acetylcysteine on fatigue , critical power , and W ′ in exercising umans
The accumulation of reactive oxygen species (ROS) is associated with muscular fatigue. The antioxidant N-acetylcysteine (NAC) can extend time to fatigue (TTF), but the effect appears to be exercise… Expand
N‐Acetylcysteine infusion does not affect glucose disposal during prolonged moderate‐intensity exercise in humans
TLDR
Unlike findings in mouse muscle ex vivo, NAC does not attenuate skeletal muscle glucose disposal or AMPK activation during moderate‐intensity exercise in humans. Expand
Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise
TLDR
It is concluded that acute NAC supplementation does not alter oxygen delivery during exercise in men and the underlying mechanisms are unknown. Expand
Effect of N-acetylcysteine on cycling performance after intensified training.
TLDR
Oral NAC supplementation improved cycling performance via an improved redox balance and promoted adaptive processes in well-trained athletes undergoing strenuous physical training. Expand
N‐acetylcysteine attenuates the decline in muscle Na+,K+‐pump activity and delays fatigue during prolonged exercise in humans
TLDR
It is confirmed that the antioxidant NAC attenuates muscle fatigue, in part via improved K+ regulation, and point to a role for ROS in muscle fatigue. Expand
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