Effects of intratracheal instillation of dactinomycin on pulmonary edema and phosphatase activity of the lung lavage fluid in rats.

@article{Giri1975EffectsOI,
  title={Effects of intratracheal instillation of dactinomycin on pulmonary edema and phosphatase activity of the lung lavage fluid in rats.},
  author={Shri N. Giri and Mannfred A. Hollinger and L. R. Kartt},
  journal={Toxicology},
  year={1975},
  volume={4 1},
  pages={53-63}
}
Intratracheal (i.t.) administration of protein synthesis inhibitors produced pulmonary edema. Of those inhibitors studied, dactinomycin (act. D) was the most potent. Severity of lung damage due to act. D was dose- and almost age-related. Maximal intensity of pulmonary edema was reached on the 3rd day following administration and remained constant for 14… CONTINUE READING