Effects of intrastriatal cannabinoids on rotational behavior in rats: interactions with the dopaminergic system.

@article{SaudoPea1998EffectsOI,
  title={Effects of intrastriatal cannabinoids on rotational behavior in rats: interactions with the dopaminergic system.},
  author={M C Sa{\~n}udo-Pe{\~n}a and Michelle Force and K Tsou and Ann S. Miller and Jennifer M. Walker},
  journal={Synapse},
  year={1998},
  volume={30 2},
  pages={221-6}
}
The effect of unilateral intrastriatal cannabinoid receptor stimulation on rotational behavior in rats was explored. The potent cannabinoid agonist CP 55,940 (5 microg/0.5 microl) induced contralateral turning when microinjected unilaterally into the striatum. The D2 dopamine agonist quinpirole reversed this contralateral rotation but failed to affect motor behavior on its own. Finally, the D1 dopamine agonist SKF 82958 inhibited movement when administered into the striatum and this inhibition… CONTINUE READING
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