Effects of intrarenal infusion of calcium entry blockers in anesthetized dogs.

@article{Dietz1983EffectsOI,
  title={Effects of intrarenal infusion of calcium entry blockers in anesthetized dogs.},
  author={John R Dietz and James O. Davis and Ronald H. Freeman and Daniel C. Villarreal and Steve Echtenkamp},
  journal={Hypertension},
  year={1983},
  volume={5 4},
  pages={482-8}
}
Renal function and renin release were studied in anesthetized, uninephrectomized dogs during intrarenal infusions of the calcium influx blockers, verapamil and nifedipine. Verapamil increased renal blood flow by 20% (p less than 0.05) but did not alter glomerular filtration rate. Verapamil produced five-to-seven fold increases in urine flow and the rates of excretion of sodium and chloride (p less than 0.01). Significant increases in the rates of excretion of potassium, calcium and magnesium… CONTINUE READING
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