Effects of intraplantar morphine on paw edema and pain-related behaviour in a rat model of repeated acute inflammation

@article{Perrot1999EffectsOI,
  title={Effects of intraplantar morphine on paw edema and pain-related behaviour in a rat model of repeated acute inflammation},
  author={Serge Perrot and Gis{\'e}le Guilbaud and Val{\'e}rie Kayser},
  journal={PAIN},
  year={1999},
  volume={83},
  pages={249-257}
}
View on Elsevier
doi.org
56 Citations
Highly Influential Citations
3
Background Citations
14
Methods Citations
4
Results Citations
6

56 Citations

Differential Behavioral Effects of Peripheral and Systemic Morphine and Naloxone in a Rat Model of Repeated Acute Inflammation

When inflammation is enhanced by recurrent stimulations, the antinociceptive effects of systemic morphine are enhanced, more likely related to central than peripheral sites of action, beyond endogenous opioid system activation.

Involvement of Interleukin‐1β in Systemic Morphine Effects on Paw Oedema in a Mouse Model of Acute Inflammation

Data demonstrate that morphine produced pro‐ or anti‐inflammatory effects in a dose‐dependent manner through peripheral or central mechanisms through peripheral and central mechanisms.

Intrathecally Injected Morphine Inhibits Inflammatory Paw Edema: The Involvement of Nitric Oxide and Cyclic-Guanosine Monophosphate

The idea that morphine can act on opioid receptors at the spinal level to produce antiedematogenic effect is supported, and that the NO/cGMP pathway seems to be an important mediator in this effect.

Peripherally mediated antinociception of the µ-opioid receptor agonist HS-731 after subcutaneous and oral administration in rats with carrageenan-induced hindpaw inflammation

The results show that systemic (s.c. and oral) treatment with the µ-opioid agonist HS-731 produces potent and long-lasting antinociception through peripheral mechanisms in rats with carrageenan-induced hindpaw inflammation, and suggest that peripheral µ-operative agonists such as HS- 731 may find clinical applications as analgesics in inflammatory pain conditions.

Intrathecally injected tramadol reduces articular incapacitation and edema in a rat model of lipopolysaccharide (LPS)-induced reactive arthritis.

QUANTITATIVE CHARACTERIZATION OF A REPEATED ACUTE JOINT INFLAMMATION MODEL IN RATS

The results suggest that the repeated administration of carrageenan might be a suitable model for determining the effects of long‐lasting treatment.

Study of the intraplantar injection of lidocaine and morphine on pain perception and the influence of morphine dependence and withdrawal on lidocaine-induced analgesia in rats.

Opioid withdrawal is one of the most common problems in clinic, and local administration of morphine with combination of lidocaine could probably produce an effective analgesia.

Modulatory Role of Morphine and Gabapentin as Anti-inflammatory Agents Alone and on Co-administration with Diclofenac in Rat Paw Edema

Combination of gabapentin and diclofenac showed synergistic anti-inflammatory effect as compared to either drug alone or combination of morphine + dicL ofenac groups.

Increase in serum level of interleukin-1 alpha mediates morphine anti-inflammatory effect in carrageenan-induced paw oedema in mice.

It is suggested that an increase in serum levels of IL-1 alpha plays an important role in the anti-inflammatory effect of morphine.

LONG-LASTING INFLAMMATORY PAIN

Adjuvant-induced monoarthritis, which has a limited effect on the general state of health of the animals compared to polyarthritic models, constitutes a robust and reproducible model in mice and is likely to be useful in patophysiological and pharmacological studies on inflammatory pain in transgenic mice.
...

References

SHOWING 1-10 OF 45 REFERENCES

Behavioural evidence for a peripheral component in the enhanced antinociceptive effect of a low dose of systemic morphine in carrageenin-induced hyperalgesic rats

Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia

Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat

Results illustrate that peripheral effects of morphine preferentially occur during inflammatory states and outline the interest of extending clinical investigations of the possible use of local injection of morphine in various inflammatory pain states.

Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat

The influence of the timing of bupivacaine infiltration on the time course of inflammation induced by two carrageenin injections seven days apart

Opioid systems in the response to inflammatory pain: Sustained blockade suggests role of κ- but not μ-opioid receptors in the modulation of nociception, behaviour and pathology

Proinflammatory effects of morphine in the rat adjuvant arthritis model.

Saline, morphine or the opioid antagonist naloxone were administered to male Wistar rats via subcutaneous osmotic pumps implanted three days prior to adjuvant disease induction by an intra-dermal injection of Mycobacterium tuberculosis in oil, finding the time of disease onset was found to be accelerated for the morphine group as compared to the saline control.

Sensitization of the nervous system, induced by two successive hindpaw inflammations, is suppressed by a local anesthetic

Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats

The enhancement of morphine antinociception by a CCKB receptor antagonist in the rat depends on the phase of inflammation and the intensity of carrageenin-induced hyperalgesia