Effects of intraocular irrigation with melphalan on rabbit retinas during vitrectomy

  title={Effects of intraocular irrigation with melphalan on rabbit retinas during vitrectomy},
  author={Yukitoshi Shimoda and Rika Hamano and Katuhiko Ishihara and Noriko Shimoda and Norikazu Hagimura and Hideo Akiyama and Shoji Kishi and A. Kaneko},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
To investigate the toxic effects of perfusion of intravitreal melphalan during vitrectomy on the rabbit retina. We performed electoretinography (ERG) in 18 eyes of 18 healthy albino rabbits before and after intraocular melphalan perfusion at concentrations of 5-, 10-, and 20-μg/ml during pars plana vitrectomy. Fellow eyes that underwent vitrectomy without melphalan served as controls. The histopathologic retinal changes were observed in both eyes of two rabbits from each group. In the 5-μg/ml… CONTINUE READING

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