Effects of intrahippocampal nicotine and neurosteroid administration on withdrawal in voluntary and chronic alcohol-drinking rats.

@article{MartnGarca2005EffectsOI,
  title={Effects of intrahippocampal nicotine and neurosteroid administration on withdrawal in voluntary and chronic alcohol-drinking rats.},
  author={Elena Mart{\'i}n-Garc{\'i}a and M G{\'o}mez Pallar{\`e}s},
  journal={Alcoholism, clinical and experimental research},
  year={2005},
  volume={29 9},
  pages={1654-63}
}
BACKGROUND Previous studies have shown that 4.6 mug of nicotine administered to the hippocampus can deteriorate learning acquisition in alcohol-drinking rats. The aim of the present study was to research whether this nicotine dose can alter the alcohol withdrawal syndrome and whether the two neurosteroids, allopregnanolone (AlloP) and pregnenolone sulfate (PregS), at doses previously reported as anxiolytic and promnesic, respectively, can modulate these effects. METHODS We used a free-choice… CONTINUE READING