Effects of intracerebroventricular injection of d-amphetamine on metabolic, respiratory, and vasomotor activities and body temperatures in the rat.


Systemic and central administration of d-amphetamine both produced dose-dependent hypothermia in the rat at ambient temperature (Ta) 8 degrees C. The hypothermia was brought about solely by a decrease in metabolic heat production. However, at both Ta 22 and 30 degrees C, d-amphetamine produced hyperthermia accompanied by behavioral excitation. The… (More)


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