Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells.

Abstract

Ca(2+)-activated K(+) currents were studied in inner hair cells (IHCs) of mature mice. I(K,f), the large-conductance Ca(2+)-activated K(+) current (BK) characteristic of mature IHCs, had a fast activation time constant (0.4 ms at -25 mV at room temperature) and did not inactivate during 170 ms. Its amplitude, measured at -25 mV, and activation time constant… (More)

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