Effects of intracellular glucopenia on pulsatile growth hormone secretion: mediation in part by somatostatin.

Abstract

We examined the effects of 2-deoxy-D-glucose (2DG)-induced intracellular glucoprivation on GH, insulin, and glucose secretory dynamics in freely moving rats bearing chronic intracerebroventricular and intracardiac venous cannulae. Intravenous administration of 2DG (400 mg/kg) caused a severe suppression in amplitude and duration of spontaneous GH surges… (More)

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