Effects of intra-cochlear perfusion of salicylates on cochlear microphonic and other auditory responses in the guinea pig.

@article{Fitzgerald1993EffectsOI,
  title={Effects of intra-cochlear perfusion of salicylates on cochlear microphonic and other auditory responses in the guinea pig.},
  author={John J. Fitzgerald and Donald A. Robertson and Brian M. Johnstone},
  journal={Hearing research},
  year={1993},
  volume={67 1-2},
  pages={147-56}
}
The ototoxic action of salicylate was investigated in the guinea pig by perfusion of both salicylate and bromosalicylate through scala tympani. The results qualitatively confirmed experiments using intravenous administration in cats (Stypulkowski, 1990), showing dose-dependent elevations in compound action potential (CAP) thresholds, increases in cochlear microphonics (CM) and level-dependent reductions in 2f1-f2 acoustic distortion products. The endocochlear potential was not significantly… CONTINUE READING