Effects of interrupted insulin treatment on fetal outcome of pregnant diabetic rats.

@article{Eriksson1989EffectsOI,
  title={Effects of interrupted insulin treatment on fetal outcome of pregnant diabetic rats.},
  author={Rickard Eriksson and Lennart Thunberg and Ulf J. Eriksson},
  journal={Diabetes},
  year={1989},
  volume={38 6},
  pages={764-72}
}
Streptozocin-induced diabetic female rats became normoglycemic after subcutaneous insertion of insulin-releasing osmotic minipumps. These female rats were mated with normal males from the same Sprague-Dawley substrain. In this substrain, the offspring of diabetic rats show a markedly increased congenital malformation rate compared with fetuses of nondiabetic rats. The pregnant diabetic rats were subjected to removal and insertion of pumps at defined gestational days that marked the beginning or… CONTINUE READING