Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation.

@article{Parihar2003EffectsOI,
  title={Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation.},
  author={Ashutosh S Parihar and Michael Coghlan and Murali M Gopalakrishnan and Char-Chang Shieh},
  journal={European journal of pharmacology},
  year={2003},
  volume={471 3},
  pages={
          157-64
        }
}
The effects of 1-ethyl-2-benzimidazolinone (1-EBIO) and riluzole on human prostate cancer cells, LNCaP and PC-3, were evaluated using rubidium (86Rb(+)) efflux and proliferation assays. 1-EBIO and riluzole evoked concentration-dependent increases in 86Rb(+) efflux from LNCaP and PC-3 cells that were sensitive to inhibition by intermediate-conductance Ca(2+)-activated K(+) channel (IK(Ca)) blockers clotrimazole and charybdotoxin. Blockers of large-conductance Ca(2+)-activated K(+) (BK(Ca… CONTINUE READING

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