Effects of interleukin-1β on sleep are mediated by the type I receptor.

@article{Fang1998EffectsOI,
  title={Effects of interleukin-1β on sleep are mediated by the type I receptor.},
  author={Jidong Fang and Ying Wang and James M. Krueger},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1998},
  volume={274 3},
  pages={R655-R660}
}
Interleukin-1β (IL-1β) is a well characterized sleep regulatory substance. To study receptor mechanisms for the sleep-promoting effects of IL-1β, sleep patterns were determined in control and IL-1 type I receptor knockout (IL-1RI KO) mice with a B6x129 background after intraperitoneal injections of saline or murine recombinant IL-1β. The IL-1RI KO mice had slightly but significantly less sleep during the dark period compared with the controls. IL-1β dose dependently increased non-rapid eye… CONTINUE READING

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Referenced Papers

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Showing 1-10 of 50 references

Interleu - kin4 attenuates rabbits ’ spontaneous sleep

  • T. Kushikata, J. Fang, Y. Wang, J. M. Krueger
  • Soc Neurosci . Abstr .
  • 1997

Interleukin-4 attenuates rabbits

  • T. Kushikata, J. Fang, Y. Wang, J. M. Krueger
  • spontaneous sleep. Soc Neurosci. Abstr
  • 1997

Gene targeting in neuroscience: the systemic approach

  • R. Gerlai
  • Trends Neurosci
  • 1996

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