Effects of interferons on tumour necrosis factor alpha production from human keratinocytes.

@article{Matsuura1998EffectsOI,
  title={Effects of interferons on tumour necrosis factor alpha production from human keratinocytes.},
  author={Keiichi Matsuura and Fujio Otsuka and Hiroshi Fujisawa},
  journal={Cytokine},
  year={1998},
  volume={10 7},
  pages={500-5}
}
Interferons (IFNs) have been reported to have pleiotrophic effects including the ability to induce the production of other cytokines in several cell types. Tumour necrosis factor alpha (TNF-alpha) is pro-inflammatory cytokine a known to be produced by a variety of cells including human keratinocytes. In the present study, we sought to determine the effects of IFNs on TNF-alpha production from human keratinocytes. IFN-gamma (50-100 ng/ml) induced TNF-alpha production dose dependently, but no… CONTINUE READING

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