Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice cultures.

@article{Mller1993EffectsOI,
  title={Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice cultures.},
  author={Matthias M{\"u}ller and Adriano Fontana and Gerhard Zbinden and Beat H. G{\"a}hwiler},
  journal={Brain research},
  year={1993},
  volume={619 1-2},
  pages={157-62}
}
In viral diseases of the CNS, both interferon-alpha/beta and interferon-gamma are produced intrathecally. At least some of the neurological symptoms associated with these diseases may be due to the effects of these cytokines. We have studied the actions of interferons on CA3 pyramidal cells in hippocampal slice cultures. Bath application of interferon-alpha/beta and interferon-gamma produced an excitatory effect on CA3 pyramidal cells and a decrease in evoked inhibitory postsynaptic potential… CONTINUE READING
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