Effects of interferon-gamma and streptolysin O on hepatic procainamide N-acetyltransferase and various microsomal cytochrome P450-dependent monooxygenases in rats.

@article{Walter1996EffectsOI,
  title={Effects of interferon-gamma and streptolysin O on hepatic procainamide N-acetyltransferase and various microsomal cytochrome P450-dependent monooxygenases in rats.},
  author={Robert L. Walter and Werner Siegmund and Eberhard Scheuch},
  journal={Immunopharmacology and immunotoxicology},
  year={1996},
  volume={18 4},
  pages={571-86}
}
Immunostimulants known to initiate cytokine production were found to inhibit processes of microsomal drug oxidation but to activate arylamine N-acetylation. The present study investigated the effects of immunstimulating doses of rat interferon-gamma (IFN gamma, 670,000 units ip) and streptolysin O (SLO, 100 HU/kg iv for 5 days) on hepatic cytosolic N-acetyltransferase (NAT) and microsomal cytochrome P450 (CYP)-dependent monooxygenases in male Wistar rats. Both IFN gamma and SLO activated NAT to… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
The present study investigated the effects of immunstimulating doses of rat interferon - gamma ( IFN gamma , 670,000 units ip ) and streptolysin O ( SLO , 100 HU / kg iv for 5 days ) on hepatic cytosolic N - acetyltransferase ( NAT ) and microsomal cytochrome P450 ( CYP)-dependent monooxygenases in male Wistar rats .
While the enhancing SLO effect on NAT could not be neutralized by the inhibitor of transcription actinomycin D , NAT stimulation by IFN gamma was abolished by actinomycin D and by the inhibitor of translation , cycloheximide .
The present study investigated the effects of immunstimulating doses of rat interferon - gamma ( IFN gamma , 670,000 units ip ) and streptolysin O ( SLO , 100 HU / kg iv for 5 days ) on hepatic cytosolic N - acetyltransferase ( NAT ) and microsomal cytochrome P450 ( CYP)-dependent monooxygenases in male Wistar rats .
The present study investigated the effects of immunstimulating doses of rat interferon - gamma ( IFN gamma , 670,000 units ip ) and streptolysin O ( SLO , 100 HU / kg iv for 5 days ) on hepatic cytosolic N - acetyltransferase ( NAT ) and microsomal cytochrome P450 ( CYP)-dependent monooxygenases in male Wistar rats .
The present study investigated the effects of immunstimulating doses of rat interferon - gamma ( IFN gamma , 670,000 units ip ) and streptolysin O ( SLO , 100 HU / kg iv for 5 days ) on hepatic cytosolic N - acetyltransferase ( NAT ) and microsomal cytochrome P450 ( CYP)-dependent monooxygenases in male Wistar rats .
All Topics