Effects of interferon and hydroxyurea on bone marrow fibrosis in chronic myelogenous leukaemia: a comparative retrospective multicentre histological and clinical study.

@article{Thiele2000EffectsOI,
  title={Effects of interferon and hydroxyurea on bone marrow fibrosis in chronic myelogenous leukaemia: a comparative retrospective multicentre histological and clinical study.},
  author={Juergen Michael Thiele and Hans Michael Kvasnicka and Annette Schmitt-Graeff and Mark Spohr and Volker Diehl and Rudolph Zankovich and Norbert Niederle and L. D. Leder},
  journal={British journal of haematology},
  year={2000},
  volume={108 1},
  pages={64-71}
}
A retrospective multicentre clinicopathological study was performed on sequential bone marrow trephine biopsies in 100 patients with Ph1+-chronic myelogenous leukaemia (CML) to elucidate the effect of interferon (IFN) alpha 2b and hydroxyurea (HU) treatment on myelofibrosis and megakaryopoiesis. According to strictly defined therapeutic regimens, 38 patients received IFN as monotherapy, 23 patients a combination of IFN and HU and 39 patients HU only. Using standardized intervals of biopsies and… CONTINUE READING

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