Effects of intercellular junction protein expression on intracellular ice formation in mouse insulinoma cells.

@article{Higgins2013EffectsOI,
  title={Effects of intercellular junction protein expression on intracellular ice formation in mouse insulinoma cells.},
  author={Adam Z Higgins and Jens Magnus Karlsson},
  journal={Biophysical journal},
  year={2013},
  volume={105 9},
  pages={
          2006-15
        }
}
The development of cryopreservation procedures for tissues has proven to be difficult in part because cells within tissue are more susceptible to intracellular ice formation (IIF) than are isolated cells. In particular, previous studies suggest that cell-cell interactions increase the likelihood of IIF by enabling propagation of ice between neighboring cells, a process thought to be mediated by gap junction channels. In this study, we investigated the effects of cell-cell interactions on IIF… CONTINUE READING
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