Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling

@inproceedings{Norambuena2011EffectsOI,
  title={Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling},
  author={Andr{\'e}s Norambuena and Martin A Schwartz},
  booktitle={Molecular biology of the cell},
  year={2011}
}
Anchorage dependence of cell growth, which is mediated by multiple integrin-regulated signaling pathways, is a key defense against cancer metastasis. Detachment of cells from the extracellular matrix triggers caveolin-1-dependent internalization of lipid raft components, which mediates suppression of Rho GTPases, Erk, and phosphatidylinositol 3-kinase in suspended cells. Elevation of cyclic adenosine monophosphate (cAMP) following cell detachment is also implicated in termination of growth… CONTINUE READING

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