Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy.

@article{Tessari2005EffectsOI,
  title={Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy.},
  author={Paolo Tessari and Anna Coracina and Edward Kiwanuka and Monica Vedovato and Monica Vettore and Anna Valerio and Michela Zaramella and Giacomo Garibotto},
  journal={Diabetes},
  year={2005},
  volume={54 10},
  pages={2968-76}
}
Although hyperhomocysteinemia, an independent cardiovascular risk factor, is common in type 2 diabetes with nephropathy, the mechanism(s) of this alteration is not known. In healthy humans, hyperinsulinemia increases methionine transmethylation, homocysteine transsulfuration, and clearance. No such data exist in type 2 diabetes either in the fasting state or in response to hyperinsulinemia. To this purpose, seven male type 2 diabetic patients with albuminuria (1.2 +/- 0.4 g/day, three with mild… CONTINUE READING
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