Effects of insulin on glucose transport and glucose transporters in rat heart.

@article{Zaninetti1988EffectsOI,
  title={Effects of insulin on glucose transport and glucose transporters in rat heart.},
  author={Daniel Zaninetti and R M Greco-Perotto and Françoise D. Assimacopoulos-Jeannet and Bernard Jeanrenaud},
  journal={The Biochemical journal},
  year={1988},
  volume={250 1},
  pages={
          277-83
        }
}
The effect of insulin on glucose transport and glucose transporters was studied in perfused rat heart. Glucose transport was measured by the efflux of labelled 3-O-methylglucose from hearts preloaded with this hexose. Insulin stimulated 3-O-methylglucose transport by: (a) doubling the maximal velocity (Vmax); (b) decreasing the Kd from 6.9 to 2.7 mM; (c) increasing the Hill coefficient toward 3-O-methylglucose from 1.9 to 3.1; (d) increasing the efficiency of the transport process (k constant… CONTINUE READING
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Protection of ischemic hearts by high glucose is mediated, in part, by GLUT-4.

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  • 2001
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Glucose transport in the heart.

  • Frontiers in bioscience : a journal and virtual library
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