Effects of insulin-like growth factors I and II on tumour-necrosis-factor-alpha-induced apoptosis in early murine embryos.

@article{Byrne2002EffectsOI,
  title={Effects of insulin-like growth factors I and II on tumour-necrosis-factor-alpha-induced apoptosis in early murine embryos.},
  author={Angela T. Byrne and Jennifer Southgate and Daniel Roy Brison and Henry J. Leese},
  journal={Reproduction, fertility, and development},
  year={2002},
  volume={14 1-2},
  pages={79-83}
}
The proposition that members of the insulin-like growth factor superfamily act as rescue factors from apoptosis in murine preimplantation embryos was tested. The cytokine tumour necrosis factor alpha (TNFalpha) was used to induce apoptosis. Zygotes were cultured for 5 days to the blastocyst stage in the presence or absence of TNFalpha and in the presence or absence of the insulin-like growth factors, IGF-I or IGF-II. Tumour necrosis factor alpha significantly increased the percentage of… CONTINUE READING

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