Effects of insulin detemir and NPH insulin on renal handling of sodium, fluid retention and weight in type 2 diabetic patients

@article{Hendriksen2011EffectsOI,
  title={Effects of insulin detemir and NPH insulin on renal handling of sodium, fluid retention and weight in type 2 diabetic patients},
  author={Kirsten Vang Hendriksen and Torben Ren Jensen and Peter Sandor Oturai and Bo F Feldt-Rasmussen},
  journal={Diabetologia},
  year={2011},
  volume={55},
  pages={46-50}
}
Aims/hypothesisIn type 2 diabetic patients, insulin detemir (B29Lys(ε-tetradecanoyl),desB30 human insulin) induces less weight gain than NPH insulin. Due to the proposed reduction of tubular action by insulin detemir, type 2 diabetic patients should have increased urinary sodium excretion, thereby reducing extracellular volume and body weight when changed from NPH insulin to insulin detemir.MethodsIn a randomised, open-labelled, two-way crossover study of 24 patients with type 2 diabetes… CONTINUE READING
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