Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle. Evidence that prostaglandins do not mediate changes in glucose uptake.

@article{Zorzano1986EffectsOI,
  title={Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle. Evidence that prostaglandins do not mediate changes in glucose uptake.},
  author={Antonio Zorzano and Thomas W. Balon and Joseph A. Jakubowski and Michael N. Goodman and Daniel Deykin and Neil Bertrand Ruderman},
  journal={The Biochemical journal},
  year={1986},
  volume={240 2},
  pages={437-43}
}
Prostaglandin generation and its inter-relation to the metabolic effects of insulin and prior exercise were examined in perfused muscle of fed rats. During a 60 min perfusion of the rat hindquarter, a substantial release of the prostaglandins PGF2 alpha, PGE2 and 6-oxoPGF1 alpha was observed. Blood cells present in the perfusate released these substances in negligible amounts indicating the prostaglandins were produced by the hindquarter. Addition of insulin to the perfusate increased both… CONTINUE READING