Effects of insulin and glucose on urea synthesis in normal man, independent of pancreatic hormone secretion.

@article{Hamberg1994EffectsOI,
  title={Effects of insulin and glucose on urea synthesis in normal man, independent of pancreatic hormone secretion.},
  author={Ole Hamberg and Hendrik Vilstrup},
  journal={Journal of hepatology},
  year={1994},
  volume={21 3},
  pages={381-7}
}
We investigated the inhibitory effect of insulin and glucose on hepatic amino- to urea-nitrogen conversion independent of endogenous insulin and glucagon secretion. Alanine-stimulated urea synthesis kinetics, as quantified by functional hepatic nitrogen clearance, i.e. the slope of the linear relation between blood alpha-amino nitrogen concentration and urea synthesis rate, were measured four times in each of six healthy volunteers, namely during spontaneous hormone responses, and during… CONTINUE READING