Effects of insecticide resistance and exposure on Plasmodium development in Anopheles mosquitoes.

  title={Effects of insecticide resistance and exposure on Plasmodium development in Anopheles mosquitoes.},
  author={Corrado Minetti and Victoria A. Ingham and Hilary Ranson},
  journal={Current opinion in insect science},

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

This review aims to elucidate the current and potential contribution of Anopheles metabolic proteins to malaria transmission and control and the roles of metabolic proteins as insecticide targets, in blood digestion and immune response as well as their contribution to insecticide resistance and Plasmodium parasite development.

The need for practical insecticide-resistance guidelines to effectively inform mosquito-borne disease control programs

It is concluded that additional testing guidelines are needed to determine practical resistance—the efficacy of vector control tools under relevant local conditions— in order to obtain programmatic impact.

Malaria transmission blocking compounds: a patent review

Among innovative inventions patented over the last 6 years, the surface-delivery of antimalarial drugs to kill transmission-stages parasites in mosquitoes holds the highest promise for success in malaria control strategies, opening completely new scenarios in malaria transmission-blocking drug discovery.

Compensatory mechanisms in resistant Anopheles gambiae AcerKis and KdrKis neurons modulate insecticide-based mosquito control

Using multidisciplinary approaches adapted to neurons isolated from resistant Anopheles gambiae AcerKis and KdrKis strains together with larval bioassays, it is demonstrated that nAChRs, and the intracellular calcium concentration represent the key components of an adaptation strategy ensuring neuronal functions maintenance.

Drug targeting of aminoacyl-tRNA synthetases in Anopheles species and Aedes aegypti that cause malaria and dengue

Structural analysis of two important aminoacyl-tRNA synthetases of Anopheles spp.

Association of Reduced Long-Lasting Insecticidal Net Efficacy and Pyrethroid Insecticide Resistance With Overexpression of CYP6P4, CYP6P3, and CYP6Z1 in Populations of Anopheles coluzzii From Southeast Côte d’Ivoire

Study findings raise concerns regarding the operational failure of standard LLINs and support the urgent deployment of vector control interventions incorporating piperonyl butoxide, chlorfenapyr, or clothianidin in areas of high resistance intensity in Côte d’Ivoire.

In-vivo and in-vitro effectiveness of three insecticides types for eradication of the tick Rhipicephalus sanguineus in dogs

Background: External parasites contribute to extensive harmful impacts on their hosts which is why control and eradication of external parasites have been included in all biosecurity plans of dog

Plasmodium falciparum Pf77 and male development gene 1 as vaccine antigens that induce potent transmission-reducing antibodies

Two Plasmodium falciparum vaccine candidates, Pf77 and PfMDV-1, have multistage expression and induce antibodies that reduce parasite transmission and merit further evaluation as TBV candidates.



Insecticide exposure impacts vector–parasite interactions in insecticide-resistant malaria vectors

Insecticide resistance leads to a selective pressure of insecticides on Plasmodium parasites, providing, to the authors' knowledge, the first evidence of genotype by environment interactions on vector competence in a natural Anopheles–Plas modium combination.

Insecticide Resistance Alleles Affect Vector Competence of Anopheles gambiae s.s. for Plasmodium falciparum Field Isolates

Insecticide resistance, which is particularly problematic for malaria control efforts, impacts vector competence towards P. falciparum and probably parasite transmission through increased sporozoite prevalence in kdr resistant mosquitoes.

Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission

It is shown that the development of P. falciparum can be rapidly and completely blocked when female Anopheles gambiae mosquitoes take up low concentrations of specific antimalarials from treated surfaces—conditions that simulate contact with a bed net.

The impact of insecticide resistance on Culex pipiens immunity

The impact of insecticide resistance in Culex pipiens, an epidemiologically important vector of a wide array of pathogens, is investigated using both isogenic laboratory strains and field‐caught mosquitoes to investigate the relative transcription of several genes involved in the immune response to pathogens.

Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae

Evidence for a survival cost associated with infection by Plasmodium parasite only in mosquito selected for insecticide resistance is provided, which suggests that the selection of insecticides resistance mutation may have disturbed the interaction between parasites and vectors, resulting in increased cost of infection.

Disrupting Mosquito Reproduction and Parasite Development for Malaria Control

Manipulating 20E pathways provides a powerful new approach to tackle malaria transmission by the mosquito vector, particularly in areas affected by the spread of insecticide resistance.

Resisting infection by Plasmodium berghei increases the sensitivity of the malaria vector Anopheles gambiae to DDT

The observed pattern indicates a cost of parasite-resistance, which suggests that the continued use of insecticides in a population of insecticide-resistant mosquitoes could select mosquitoes to be more susceptible to Plasmodium infection, thus further decreasing the efficacy of the control.

Insecticide resistance genes affect Culex quinquefasciatus vector competence for West Nile virus

Results showed that insecticide resistance mechanisms enhanced vector competence for WNV and may have a significant impact on transmission dynamics of arboviruses.