Corpus ID: 21945206

Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.

@article{Gerli2003EffectsOI,
  title={Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.},
  author={S. Gerli and M. Mignosa and G. D. Di Renzo},
  journal={European review for medical and pharmacological sciences},
  year={2003},
  volume={7 6},
  pages={
          151-9
        }
}
BACKGROUND Women with oligomenorrhea and polycystic ovaries show a high incidence of ovulation failure perhaps linked to insulin resistance and related metabolic features. A small number of reports shows that inositol improves ovarian function. Futhermore, in these trials the quality of evidence supporting ovulation is suboptimal, and few studies have been placebo-controlled. The aim of this study was to use a double-blind, placebo-controlled approach with detailed assessment of ovarian… Expand
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TLDR
An overview on the clinical outcomes of the MYO use as a treatment to improve ovarian function and metabolic and hormonal parameters in women with PCOS is provided. Expand
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TLDR
The trial sequential analysis of insulin meta-analysis illustrates that the cumulative z-curve crossed the monitoring boundary, providing firm evidence of the intervention effect of MI in improving the metabolic profile of women with PCOS, concomitantly reducing their hyperandrogenism. Expand
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TLDR
Myo-inositol has proven to be a new treatment option for patients with PCOS and infertility and the achieved pregnancy rates are at least in an equivalent or even superior range than those reported using metformin as an insulin sensitizer. Expand
Efficacy of combination therapy of inositols, antioxidants and vitamins in obese and non-obese women with polycystic ovary syndrome: an observational study
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Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials
TLDR
This systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement inPCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS. Expand
Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study
  • P. Artini, O. M. Di Berardino, +4 authors V. Cela
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2013
TLDR
Myo-inositol administration improves reproductive axis functioning in PCOS patients reducing the hyperinsulinemic state that affects LH secretion, and insulin sensitivity, expressed as glucose-to-insulin ratio and HOMA index resulted significantly improved after 12 weeks of treatment. Expand
A prospective randomised controlled study on the effects of myoinositol on ovarian functions and metabolic factors in women with polycystic ovarian syndrome
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorder affecting five to ten percent women of reproductive age group. Typically PCOS is characterized by hyperandrogenism,Expand
Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS)
TLDR
The two insulin-sensitizers, metformin and myo-inositol, show to be useful in PCOS women in lowering BMI and ameliorating insulin sensitivity, and improving menstrual cycle without significant differences between the two treatments. Expand
Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials
TLDR
Inositol appears to regulate menstrual cycles, improve ovulation and induce metabolic changes in polycystic ovary syndrome; however, evidence is lacking for pregnancy, miscarriage or live birth. Expand
The menstrual cycle regularization following d-chiro-inositol treatment in PCOS women: a retrospective study
TLDR
The use of d-chiro-inositol treatment is associated to clinical benefits for many women affected by PCOS including the improvement in insulin resistance and menstrual cycle regularity. Expand
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