Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts.

@article{Pegg1981EffectsOI,
  title={Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts.},
  author={Anthony E. Pegg and Ronald T. Borchardt and James K. Coward},
  journal={The Biochemical journal},
  year={1981},
  volume={194 1},
  pages={79-89}
}
1. A number of compounds known to inhibit polyamine biosynthesis at various steps in the biosynthetic pathway were tested for their ability to inhibit growth and decrease polyamine concentrations in virally transformed mouse fibroblasts (SV-3T3 cells). 2. Virtually complete inhibition of growth was produced by the inhibitors of ornithine decarboxylase alpha-methylornithine and alpha-difluoromethylornithine and by the inhibitors of S-adenosylmethionine decarboxylase 1,1'-[(methylethanediylidene… CONTINUE READING
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