Effects of inhibitors of ornithine decarboxylase on the differentiation of mouse neuroblastoma cells.

@article{Chen1983EffectsOI,
  title={Effects of inhibitors of ornithine decarboxylase on the differentiation of mouse neuroblastoma cells.},
  author={Kuang Yu Chen and Dana Nau and Alice Y C Liu},
  journal={Cancer research},
  year={1983},
  volume={43 6},
  pages={2812-8}
}
(R, S)-alpha-Fluoromethylornithine (alpha-FMO), a catalytic irreversible inhibitor of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17), induced the differentiation of N2a mouse neuroblastoma cells. The effect of alpha-FMO was concentration dependent; approximately 50% of the cell population exhibited neurite outgrowth in the presence of 1 mM alpha-FMO, while higher concentrations caused severe growth inhibition and cell death. The effect of 1 mM alpha-FMO on neuroblastoma… CONTINUE READING