Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility.

  title={Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility.},
  author={Victor Gil and Diana Gallego and Marcel Jimenez},
  journal={British journal of pharmacology},
  volume={164 2b},
BACKGROUND AND PURPOSE The role of hydrogen sulphide (H₂S) as a putative endogenous signalling molecule in the gastrointestinal tract has not yet been established. We investigated the effect of D,L-propargylglycine (PAG), an inhibitor of cystathionine γ-lyase (CSE), amino-oxyacetic acid (AOAA) and hydroxylamine (HA), inhibitors of cystathionine β-synthase (CBS) on rat colonic motility. EXPERIMENTAL APPROACH Immunohistochemistry, H₂S production, microelectrode and organ bath recordings were… CONTINUE READING


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