Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes.

@article{Carlson1998EffectsOI,
  title={Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes.},
  author={Gary P. Carlson and Darina Hynes and Nancy A Mantick},
  journal={Toxicology letters},
  year={1998},
  volume={98 3},
  pages={131-7}
}
Much of the toxicity of styrene is associated with its bioactivation to styrene oxide. Both liver and lung have been shown to carry out this metabolic step, but there are differences reported as to which isomers of cytochrome P450 are responsible for this biotransformation in various species and tissues. CYP2E1, CYP2F, CYP2B, CYP1A1/2 and CYP2C11 have all been implicated. In the current study, alpha-naphthoflavone (alphaNF) and alpha-methylbenzylaminobenzotriazole (MBA), selective inhibitors of… CONTINUE READING

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