Effects of inhibition of hepatic sulfotransferase activity on renal genotoxicity induced by lucidin‐3‐O‐primeveroside

  title={Effects of inhibition of hepatic sulfotransferase activity on renal genotoxicity induced by lucidin‐3‐O‐primeveroside},
  author={Y. Ishii and A. Kijima and S. Takasu and K. Ogawa and T. Umemura},
  journal={Journal of Applied Toxicology},
  pages={650 - 657}
  • Y. Ishii, A. Kijima, +2 authors T. Umemura
  • Published 2019
  • Chemistry, Medicine
  • Journal of Applied Toxicology
  • Sulfotransferase 1A (SULT1A) expression is lower in the liver of humans than that of rodents. Therefore, species differences should be taken into consideration when assessing the risk of rodent hepatocarcinogens metabolically activated by SULT1A in humans. Although some renal carcinogens require SULT1A‐mediated activation, it is unclear how SULT1A activity in the liver affects renal carcinogens. To explore the effects of SULT1A activity in the liver on genotoxicity induced by SULT1A‐activated… CONTINUE READING
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