Effects of inhibition of alpha-CGRP receptors on cardiac and peripheral vascular dynamics in conscious dogs with chronic heart failure.

@article{Shen2003EffectsOI,
  title={Effects of inhibition of alpha-CGRP receptors on cardiac and peripheral vascular dynamics in conscious dogs with chronic heart failure.},
  author={You-tang Shen and John J Mallee and Laurence K. Handt and David B. Gilberto and Joseph J. Lynch and Richard J. Hargreaves and Kenneth S. Koblan and Robert J. Gould and Stefanie A. Kane},
  journal={Journal of cardiovascular pharmacology},
  year={2003},
  volume={42 5},
  pages={656-61}
}
Whether endogenous calcitonin gene-related peptide (CGRP) plays a role in heart failure is unclear. Seven dogs were instrumented with left ventricular (LV) pressure gauges, pacers, coronary occluder and aortic, atrial, and coronary sinus catheters. Hemodynamic recordings and response to alpha-CGRP challenge were obtained for baseline in the conscious state. Rapid pacing (240 beats/min) was then initiated. The coronary artery was occluded for 90 minutes followed by reperfusion after 2 weeks of… CONTINUE READING

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