Effects of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects.

@article{Lay2001EffectsOI,
  title={Effects of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects.},
  author={John C. Lay and Kirby L. Zeman and Andrew J Ghio and William Drew Bennett},
  journal={Inhalation toxicology},
  year={2001},
  volume={13 12},
  pages={1065-78}
}
Pulmonary inflammation secondary to oxidant generation catalyzed by transition metals associated with inhaled particles is one factor postulated to underlie the acute health effects of particulate air pollution. We postulated that inhaled iron oxide particles with associated amounts of soluble iron should induce mild pulmonary inflammation and lead to altered alveolar epithelial integrity and altered gas exchange. To test this hypothesis we examined the effects of inhaled iron oxide particles… CONTINUE READING