Effects of inhalational anesthetics on verapamil pharmacokinetics in dogs.

@article{Chelly1986EffectsOI,
  title={Effects of inhalational anesthetics on verapamil pharmacokinetics in dogs.},
  author={Jacques Chelly and Einar Hysing and Darrell R. Abernethy and M F Doursout and R G Merin},
  journal={Anesthesiology},
  year={1986},
  volume={65 3},
  pages={266-71}
}
Six dogs were chronically instrumented in order to collect aortic blood samples and record mean arterial pressure, cardiac output and heart rate. Each animal received verapamil 200 micrograms X kg-1 by 10-min intravenous infusions on four occasions in random sequence: awake, and during halothane 1.2%, enflurane 2.5%, and isoflurane 1.6% anesthesia. Rate of initial distribution of verapamil was reduced during anesthetic exposure. Verapamil intercompartmental clearance from the central… CONTINUE READING