Effects of infusion of L-arginine into the left anterior descending coronary artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteries.

@article{DuboisRand1992EffectsOI,
  title={Effects of infusion of L-arginine into the left anterior descending coronary artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteries.},
  author={Jean Luc P Dubois-Rand{\'e} and Robin Zelinsky and F Roudot and Pierre Etienne Chabrier and Alain Castaigne and Herbert Geschwind and Serge Adnot},
  journal={The American journal of cardiology},
  year={1992},
  volume={70 15},
  pages={1269-75}
}
Hypercholesterolemia and atherosclerosis are conditions associated with impaired endothelium-dependent relaxation. In hypercholesterolemic animals, intravenous administration of L-arginine, the precursor of nitric oxide, normalizes endothelium-dependent vasodilator activity. In the present study, we questioned whether intracoronary administration of L-arginine in patients with coronary artery disease could improve coronary vascular reactivity to acetylcholine. Thirteen hypercholesterolemic… CONTINUE READING

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