Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport.

@article{Li1996EffectsOI,
  title={Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport.},
  author={Yanxin Li and John J. M. Bergeron and Lizhong Luo and W J Ou and David Y. Thomas and Christine Y Kang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 18},
  pages={9606-11}
}
The HIV-1 envelope glycoprotein gp120 displays inefficient intracellular transport, which is caused by its retention in the endoplasmic reticulum. Coexpression in insect cells (Sf9) of HIV-1 gp120 with calnexin has shown that their interaction was modulated by the signal sequence of HIV-1 gp120. gp120, with its natural signal sequence, showed a prolonged association with calnexin with a t1/2 of greater than 20 min. Replacement of the natural signal sequence with the signal sequence from… CONTINUE READING

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