Effects of increasing doses of a bolus injection and an intravenous long-term therapy of taurolidine on subcutaneous (metastatic) tumor growth in rats

@article{Braumann2005EffectsOI,
  title={Effects of increasing doses of a bolus injection and an intravenous long-term therapy of taurolidine on subcutaneous (metastatic) tumor growth in rats},
  author={Chris Braumann and Marco Schoenbeck and Charalambos Menenakos and Maik Kilian and Christoph Andreas Jacobi},
  journal={Clinical & Experimental Metastasis},
  year={2005},
  volume={22},
  pages={77-83}
}
Background experimental studies have shown that taurolidine suppresses intraperitoneal tumor growth following local application in rats. In opposite, a single intravenous therapy affected neither intraperitoneal nor subcutaneous growth of malignancies. Thus, an intravenous long-term therapy with taurolidine was investigated in rats after administration of a subcutaneous tumor load. VEGF and TNFα production and their effects on tumor growth have not been elucidated so far. Methods VEGF and TNF… CONTINUE READING

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