Effects of increasing doses of 1 alpha-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women.

@article{Gallagher1994EffectsOI,
  title={Effects of increasing doses of 1 alpha-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women.},
  author={John Christopher Gallagher and Charles W. Bishop and Joyce C. Knutson and Richard B. Mazess and Hector F DeLuca},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1994},
  volume={9 5},
  pages={
          607-14
        }
}
This study is the first reported administration of 1 alpha-hydroxyvitamin D2 (1 alpha-OHD2) to human subjects. A total of 15 postmenopausal osteopenic women were given increasing oral doses of 1 alpha-OHD2, beginning with a low dose of 0.5 microgram/day. In 15 subjects, the doses were raised at weekly intervals to 1.0, 2.0, 4.0, and 5.0 micrograms/day, and in 5 of these subjects, the dose was further increased to 8.0 or 10.0 micrograms/day. Mean urine calcium +/- SEM showed a dose-related… CONTINUE READING

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