Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism.

@article{Niswender1997EffectsOI,
  title={Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism.},
  author={Kevin D. Niswender and Masakazu Shiota and Catherine Postic and Alan D. Cherrington and Mark A Magnuson},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 36},
  pages={22570-5}
}
The relationship between glucokinase (GK) gene copy number and glucose homeostasis was studied in transgenic mice with additional copies of the entire GK gene locus (Niswender, K. D., Postic, C., Jetton, T. L., Bennett, B. D., Piston, D. W., Efrat, S., and Magnuson, M. A. (1997) J. Biol. Chem. 272, 22564-22569). The plasma glucose concentration was reduced by 25 +/- 3% and 37 +/- 4% in mice with one or two extra copies of the gene locus, respectively. The basis for the hypoglycemic phenotype… CONTINUE READING

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