Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites.

@article{Stevens2002EffectsOI,
  title={Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites.},
  author={Randy M. Stevens and M. Salik Jahania and Jennifer E Stivers and Robert M. Mentzer and Robert D. Lasley},
  journal={The Annals of thoracic surgery},
  year={2002},
  volume={73 4},
  pages={1261-6}
}
BACKGROUND There have been numerous studies examining the role of nitric oxide (NO) in myocardial ischemia-reperfusion injury; however, few studies have included measurements of NO or related reactive nitrogen species. The purpose of this study was to determine the effects of in vivo regional myocardial ischemia on interstitial fluid (ISF) reactive nitrogen species. METHODS Open chest pigs were submitted to one of three protocols: (1) 15 minutes coronary occlusion and 2 hours reperfusion, (2… CONTINUE READING

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