Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H1 and H2 receptors.

Abstract

Imidazolylpropylguanidines derived from impromidine and arpromidine are more potent and efficacious agonists at the guinea pig histamine H2 receptor (gpH2R) than at the human H2R (hH2R) in the GTPase assay. Additionally, such guanidines are histamine H1 receptor (H1R) antagonists with preference for the human relative to the guinea pig receptor. The purpose… (More)

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@article{Xie2007EffectsOI, title={Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H1 and H2 receptors.}, author={Sheng-xue Xie and Fabian Schalkhausser and Qi-zhuang Ye and Roland Seifert and Armin Buschauer}, journal={Archiv der Pharmazie}, year={2007}, volume={340 1}, pages={9-16} }