Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin.

@article{Heidt2008EffectsOI,
  title={Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin.},
  author={Sebastiaan Heidt and Dave L Roelen and Chantal Eijsink and Cees van Kooten and Franz H J Claas and Arend Mulder},
  journal={Transplantation},
  year={2008},
  volume={86 9},
  pages={1292-300}
}
BACKGROUND Humoral immunity is increasingly recognized as an important factor in the rejection of organ transplants. In general, humoral rejection is treated with standard immunosuppressive drugs. The direct effect of these immunosuppressive drugs on B cells is not well known. METHODS Purified human B cells devoid of T cells were stimulated with CD40L expressing L cells, or by anti-CD40 mAb with or without Toll-like receptor triggering, all in the presence of B-cell activating cytokines… CONTINUE READING
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Grinyó. Calcineurin-inhibitor-sparing immunosuppressive

  • O Bestard, JM Cruzado
  • E-mail: txpl@med.cornell.edu European Editorial…
  • 2008

Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells

  • W Gao, Y Lu, B El Essawy
  • Am J Transplant
  • 2007
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