Effects of immunological sensitization on the responses and sensitivity of guinea pig airways to bronchoconstrictors. Modulation by selective inhibition of arachidonic acid metabolism.

@article{Saad1983EffectsOI,
  title={Effects of immunological sensitization on the responses and sensitivity of guinea pig airways to bronchoconstrictors. Modulation by selective inhibition of arachidonic acid metabolism.},
  author={Maan H. Saad and John F. Burka},
  journal={Canadian journal of physiology and pharmacology},
  year={1983},
  volume={61 8},
  pages={
          876-87
        }
}
  • M. Saad, J. Burka
  • Published 1 August 1983
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
The force generated by tracheal spirals and lung parenchymal strips from normal and ovalbumin-sensitized guinea pigs was measured in vitro, after challenge with histamine, carbachol, leukotriene (LT) C4, LTD4, or a prostaglandin endoperoxide analog (U-44069). The responses and sensitivity of airway tissues to the above agonists were identical in normal and sensitized animals. Treatment of tracheal spirals with indomethacin (8.5 microM), phenidone (185 microM), and nordihydroguaiaretic acid… Expand
Modification by indomethacin of airway contractile responses in normal and sensitized guinea-pigs.
TLDR
It is concluded that immunological sensitization produced a non-specific hyperresponsiveness in trachea and lung parenchymal strips. Expand
Sensitization does not alter phasic and tonic responses to carbachol in isolated epithelium-free guinea-pig trachea.
TLDR
Results demonstrate that immunologic sensitization and challenge do not appear to elicit a defect in the phasic or tonic responses of receptor mediated contractions in airway smooth muscle and suggest there is no alteration in the handling of Ca2+ in smooth muscle from sensitized and challenged guinea-pig trachea. Expand
Bronchodilator‐mediated relaxation of normal and ovalbumin‐sensitized guinea‐pig airways: lack of correlation with lung adenylate cyclase activation
TLDR
It was concluded that immunological sensitization to ovalbumin does not induce hypoactivity of relaxant drug receptors and/or the adenylate cyclase system of the airway tissues of the guinea‐pig. Expand
Histamine-evoked acetylcholine release in sensitized tracheal preparation.
TLDR
The results show that sensitization causes a change in the components of the contractile response to histamine rather than bronchial hyper-responsiveness to this agent, suggesting that muscarinic M2 receptor dysfunction alone is not sufficient to cause bronchia hyper- Responsiveness. Expand
Mediators of arachidonic acid‐induced contractions of indomethacin‐treated guinea‐pig airways: leukotrienes C4 and D4
TLDR
It was concluded that immunological sensitization does not alter AA metabolism via the lipoxygenase pathway in guinea‐pig airways and the mediators of AA‐induced contraction are leukotrienes C4 and D4. Expand
Adenosine‐induced bronchoconstriction of isolated lung and trachea from sensitized guinea‐pigs
TLDR
Sensitization by antigen challenge revealed a bronchoconstrictor response of isolated airway preparations to adenosine, related to the clinical situation where only asthmatic subjects respond toadenosine by bronchconstriction and suggests that the sensitization may destabilize inflammatory cells for mediator release by adenosines. Expand
Release of leukotriene C4 from guinea pig trachea.
TLDR
The results demonstrate the hitherto unproved capability of the large airways to synthesize leukotrienes and emphasize the importance of examining their role in asthma. Expand
Effect of Desmodium adscendens fraction F1 (DAF1) on tone and agonist‐induced contractions of guinea pig airway smooth muscle
Cumulative concentration‐response curves (CCRC) of histamine, carbachol and leukotriene D, (LTD4), and relaxation curves were used to evaluate the nature of the modulation of allergic airway smoothExpand
Some properties of calcium-induced contraction in the isolated human and guinea-pig tracheal smooth muscle.
TLDR
It is concluded that active tone in the two different tracheal muscles were controlled by different processes; that different arachidonate by-products may exert an effect on basal tone inThe two different muscles; and that different plasma membrane Ca channels may be operative under basal conditions in the different muscles. Expand
Non‐specific Hyperreactivity to Pharmacological Stimuli in Tracheal and Lung Parenchymal Strips of Actively Sensitized Guinea‐pigs
TLDR
The responsiveness of tracheal and lung parenchymal strips isolated from actively sensitized guinea‐pigs to CaCl2, K+‐depolarized tissue, KCl, acetylcholine and histamine was compared to show the existence of a non‐specific increase in responsiveness in the airway smooth muscle from sensitized animals. Expand
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Bronchodilator‐mediated relaxation of normal and ovalbumin‐sensitized guinea‐pig airways: lack of correlation with lung adenylate cyclase activation
TLDR
It was concluded that immunological sensitization to ovalbumin does not induce hypoactivity of relaxant drug receptors and/or the adenylate cyclase system of the airway tissues of the guinea‐pig. Expand
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It was concluded that immunological sensitization does not alter AA metabolism via the lipoxygenase pathway in guinea‐pig airways and the mediators of AA‐induced contraction are leukotrienes C4 and D4. Expand
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