Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion.

@article{Zhang2010EffectsOI,
  title={Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion.},
  author={Zheng Zhang and Yuxiao Lai and Lin Chun Yu and Jiandong Ding},
  journal={Biomaterials},
  year={2010},
  volume={31 31},
  pages={7873-82}
}
This paper examines the effects of immobilizing sites of a bioactive ligand on its biological efficacy in a self assembly biomaterial. We synthesized an amphiphilic block copolymer PCLA-PEG-PCLA (PCLA: poly(epsilon-caprolactone-co-lactide), PEG: poly(ethylene glycol)), and then achieved immobilization of arginine-glycine-aspartate (RGD) peptides into either hydrophobic PCLA blocks or hydrophilic PEG blocks. The block copolymers could self assemble into hydrogels composed of percolated micelle… CONTINUE READING
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  • K Hozumi, D Otagiri, Y Yamada, A Sasaki, C Fujimori, Y Wakai
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