Effects of imipramine or GABA(B) receptor ligands on the immobility, swimming and climbing in the forced swim test in rats following discontinuation of cocaine self-administration.

@article{Frankowska2010EffectsOI,
  title={Effects of imipramine or GABA(B) receptor ligands on the immobility, swimming and climbing in the forced swim test in rats following discontinuation of cocaine self-administration.},
  author={Małgorzata Frankowska and Anna Gołda and Karolina Wydra and Piotr Gruca and Mariusz Papp and Małgorzata Filip},
  journal={European journal of pharmacology},
  year={2010},
  volume={627 1-3},
  pages={142-9}
}
We tested if discontinuation of cocaine self-administration can lead to the development of depressive-like symptoms in the forced swim test expressed as changes in immobility, swimming and climbing behaviors in rats. A "yoked" procedure in which rats were run simultaneously in groups of three, with two rats received the passive injection of cocaine or saline, was employed. Later, we examined whether acute treatment with the classical antidepressant imipramine or GABA(B) receptor ligands could… CONTINUE READING

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