Effects of imidazolines on neurogenic contraction in isolated urinary bladder detrusor strips from rabbit.

  title={Effects of imidazolines on neurogenic contraction in isolated urinary bladder detrusor strips from rabbit.},
  author={Hong-mei He and Lei-ming Ren and He-lin Tian and Hai-gang Lu and Ding Zhao},
  journal={Canadian journal of physiology and pharmacology},
  volume={90 2},
  • Hong-mei He, L. Ren, Ding Zhao
  • Published 6 February 2012
  • Biology, Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
Moxonidine and clonidine, which are imidazoline compounds, are sympathetic modulators used as centrally acting antihypertensive drugs. Moxonidine, clonidine, and agmatine produce extensive effects in mammalian tissues via imidazoline recognition sites (or receptors) or α(2)-adrenoceptors. To investigate the effects of imidazolines on the function of the urinary bladder, we tested the effects of moxonidine, clonidine, and agmatine on the neurogenic contraction induced by electric field… 
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